The brain tumour glioblastoma (GBM) remains one of the deadliest malignancies and is not curable despite aggressive conventional treatments. There are two major challenges that prevent efficient GBM treatment: heterogeneity and therapeutic resistance. Studies have shown that the tumour microenvironment (TME) is a complex and dynamic milieu that drives treatment resistance. However, there is a lack of molecular understanding of GBM therapeutic resistance in a spatial context and of representative tumour models that mimic GBM-immune cell interactions in humans. In the GOdyno project, we will address these challenges to combat therapy resistance: first, by establishing patient avatars in the laboratory that recapitulate the characteristics of dynamic tumours; and second, by exploring the complexity of cellular and molecular interactions of GBM stem cells in their TME after treatments.

We are open for collaborations, if you’re interested please contact Barbara Breznik Vittori, PhD

 

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