{"id":277,"date":"2018-03-07T16:06:51","date_gmt":"2018-03-07T15:06:51","guid":{"rendered":"http:\/\/projects.nib.si\/hep3dgentox\/?page_id=277"},"modified":"2021-03-18T15:19:19","modified_gmt":"2021-03-18T14:19:19","slug":"project-phases-and-realisation","status":"publish","type":"page","link":"https:\/\/projects.nib.si\/hep3dgentox\/project-phases-and-realisation\/","title":{"rendered":"Project phases and realisation"},"content":{"rendered":"

\"Fig<\/p>\n

WP1: Development of advanced 3D in vitro spheroid models with enhanced liver-specific functions from hepatic cell lines<\/strong><\/p>\n

Task 1.1: To develop a 3D in vitro cell model under static conditions<\/em><\/p>\n

Task 1.2: To develop a 3D in vitro cell model under dynamic conditions<\/em><\/p>\n

WP2: 3D scaffolds with controlled architecture to generate 3D hepatic structure <\/strong><\/p>\n

Task 2.1: To prepare scaffolds from biocompatible biopolymers <\/em><\/p>\n

Task 2.2: To develop the hepatic 3D in vitro cell model on scaffolds<\/em><\/p>\n

WP3: Application of traditional methodologies of genotoxicology to 3D in vitro<\/em> cell models <\/strong><\/p>\n

Task 3.1 To bring genotoxicology methodologies forward from 2D to 3D<\/em><\/p>\n

Task 3.2: To study the cellular and molecular processes related to genotoxicity and cancer development in the newly developed 3D cell models<\/em><\/p>\n

WP4: Validation of newly developed 3D in vitro<\/em> models for genotoxicity assessment using a set of chemicals from the EURL ECVAM list<\/strong><\/p>\n

Task 4.1: To validate hepatic 3D in vitro cell models in the form of spheroids <\/em><\/p>\n

Task 4.2: To validate hepatic 3D in vitro cell models developed on scaffolds <\/em><\/p>\n

WP5: Analyses of gene and protein expression in the newly developed 3D in vitro<\/em> cell models <\/strong><\/p>\n

Task 5.1: To identify the predictive biomarker genes involved in the metabolism and DNA damage response upon exposure to compounds from the EURL ECVAM list<\/em><\/p>\n

Task 5.2: Protein expression of predictive biomarker genes for metabolism and genotoxic effects upon exposure to compounds from the EURL ECVAM list<\/em><\/p>\n

WP6: Project management and dissemination activities<\/strong><\/p>\n

Task 6.1: Project and risk management activities<\/em><\/strong><\/p>\n

Task 6.2: Dissemination<\/em><\/strong><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

WP1: Development of advanced 3D in vitro spheroid models with enhanced liver-specific functions from hepatic cell lines Task 1.1: To develop a 3D in vitro cell model under static conditions Task 1.2: To develop a 3D in vitro cell model under dynamic conditions WP2: 3D scaffolds with controlled architecture to generate 3D hepatic structure Task […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-277","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/P7OqMV-4t","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/projects.nib.si\/hep3dgentox\/wp-json\/wp\/v2\/pages\/277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/projects.nib.si\/hep3dgentox\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/projects.nib.si\/hep3dgentox\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/projects.nib.si\/hep3dgentox\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/projects.nib.si\/hep3dgentox\/wp-json\/wp\/v2\/comments?post=277"}],"version-history":[{"count":12,"href":"https:\/\/projects.nib.si\/hep3dgentox\/wp-json\/wp\/v2\/pages\/277\/revisions"}],"predecessor-version":[{"id":380,"href":"https:\/\/projects.nib.si\/hep3dgentox\/wp-json\/wp\/v2\/pages\/277\/revisions\/380"}],"wp:attachment":[{"href":"https:\/\/projects.nib.si\/hep3dgentox\/wp-json\/wp\/v2\/media?parent=277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}