Although the plant immune system has traditionally been divided into salicylic acid (SA)-dependent defence against pathogens and JA-dependent defence against pests, recent research has revealed complex crosstalk between these two pathways. For example, following Pseudomonas <\/em>DC3000 AvrRpt2 infection of Arabidopsis<\/em>, SA-related gene expression was observed within the area of the cell death zone, while JA-related gene expression was observed in surrounding tissues. A similar pattern was observed in the interaction between the pathogenic fungus Fusarium oxysporum<\/em> and Arabidopsis<\/em> roots. Interestingly, the area of cell death showed early activation of SA pathways and late activation of JA pathways. Our group has previously shown that RBOHD, a gene required for the generation of apoplastic ROS, is required for the spatial accumulation of SA in potato defence against the pathogen PVY, and that RBOHD is under the transcriptional regulation of SA. The importance of redox status was also observed in JA-dependent changes in redox status in response to wounding in Arabidopsis<\/em>. It has recently been shown that SA augments the ROS wave, while JA suppresses it during responses to local wounding.<\/p>\n\n\n\n Several hypotheses have been proposed to explain these observations, including complex feedback loops between immune signalling pathways, spatially regulated gene expression of the different hormonal pathways, distinct reactions of different cell types surrounding the injury and changes in transport efficiency as a reaction to infection. However, the exact mechanism behind these observations remains unknown. By incorporating high-resolution spatiotemporal data and realistic 3D leaf geometry into mechanistic models, we aim to capture the spatial dynamics of immune signalling and elucidate the mechanisms underlying pest and pathogen resistance in potato.<\/strong><\/p>\n\n\n\n <\/p>\n\n\n\n Graphical Summary<\/strong><\/span><\/p>\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" Plants have evolved sophisticated mechanisms to defend against biotic stressors. Pathogen infection triggers a two-tiered immune response, comprising pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). PTI is activated by the recognition of conserved pathogen-associated molecular patterns (PAMPs) by cell surface receptors, while ETI is triggered by the detection of pathogen effectors by intracellular immune receptors. … Continue reading “Project overview”<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"page-fullwidth.php","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/Ph8N9q-e","jetpack-related-posts":[{"id":40,"url":"https:\/\/projects.nib.si\/spatiotemporal\/","url_meta":{"origin":14,"position":0},"title":"Project description","author":"ablejec","date":"05\/04\/2016","format":false,"excerpt":"In the face of climate change and the increasing prevalence of pests and diseases, understanding the complex molecular dynamics of plant defense is critical. This project aims to develop a novel systems biology pipeline, integrating high-resolution spatiotemporal data and 3D computational modeling, to elucidate the molecular mechanisms of plant defense\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":30,"url":"https:\/\/projects.nib.si\/spatiotemporal\/references\/","url_meta":{"origin":14,"position":1},"title":"Publications","author":"ablejec","date":"05\/04\/2016","format":false,"excerpt":"No publications yet.","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"_links":{"self":[{"href":"https:\/\/projects.nib.si\/spatiotemporal\/wp-json\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/projects.nib.si\/spatiotemporal\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/projects.nib.si\/spatiotemporal\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/projects.nib.si\/spatiotemporal\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/projects.nib.si\/spatiotemporal\/wp-json\/wp\/v2\/comments?post=14"}],"version-history":[{"count":42,"href":"https:\/\/projects.nib.si\/spatiotemporal\/wp-json\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":653,"href":"https:\/\/projects.nib.si\/spatiotemporal\/wp-json\/wp\/v2\/pages\/14\/revisions\/653"}],"wp:attachment":[{"href":"https:\/\/projects.nib.si\/spatiotemporal\/wp-json\/wp\/v2\/media?parent=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/i0.wp.com\/projects.nib.si\/spatiotemporal\/wp-content\/uploads\/sites\/85\/2026\/08\/project-overview.png?resize=586%2C536\")
<\/figure>\n<\/div>\n\n\n