{"id":40,"date":"2016-04-05T22:31:14","date_gmt":"2016-04-05T22:31:14","guid":{"rendered":"http:\/\/projects.nib.si\/trust-nk\/?page_id=40"},"modified":"2026-07-28T14:36:28","modified_gmt":"2026-07-28T13:36:28","slug":"short-description","status":"publish","type":"page","link":"https:\/\/projects.nib.si\/trust-nk\/","title":{"rendered":"Short description"},"content":{"rendered":"<p>The TRUST-NK project aims to dissect glioblastoma response to cell-based therapy in a spatial context, focusing on NK cell therapy combined with the TGF-\u03b2 inhibitor galunisertib and the IL-15 agonist N-803. Using a clinically relevant tumor organoid model that recapitulates the patient tumor microenvironment, the project will identify and characterize glioblastoma cell states, particularly glioma stem-like cells, which respond to or resist therapy, together with their gene expression profiles within the TME.<\/p>\n<p><strong>This work will clarify how distinct tumor cell states contribute to progression and resistance to NK cell-mediated immunotherapy.<\/strong><\/p>\n<p>This project is financed by the\u00a0<a href=\"https:\/\/www.aris-rs.si\/sl\/\" target=\"_blank\" rel=\"noopener\">Slovenian Research and Innovation Agency (ARIS)<\/a>.<br \/>Project ID: <em>Z3-70129<\/em><br \/>Duration: <em>01.03.2026 \u2013 28.2.2028 <\/em><\/p>\n<p>&nbsp;<\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"477\" data-permalink=\"https:\/\/projects.nib.si\/trust-nk\/short-description\/arislogoang_zmanjsan-za-na-web\/\" data-orig-file=\"https:\/\/i0.wp.com\/projects.nib.si\/trust-nk\/wp-content\/uploads\/sites\/75\/2026\/07\/ARISLogoAng_zmanjsan-za-na-web.jpg?fit=1712%2C354&amp;ssl=1\" data-orig-size=\"1712,354\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"ARISLogoAng_zmanjsan za na web\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/projects.nib.si\/trust-nk\/wp-content\/uploads\/sites\/75\/2026\/07\/ARISLogoAng_zmanjsan-za-na-web.jpg?fit=1024%2C212&amp;ssl=1\" class=\"alignnone size-full wp-image-477\" src=\"https:\/\/i0.wp.com\/projects.nib.si\/trust-nk\/wp-content\/uploads\/sites\/75\/2026\/07\/ARISLogoAng_zmanjsan-za-na-web.jpg?resize=1712%2C354\" alt=\"\" width=\"1712\" height=\"354\" \/><\/p>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The TRUST-NK project aims to dissect glioblastoma response to cell-based therapy in a spatial context, focusing on NK cell therapy combined with the TGF-\u03b2 inhibitor galunisertib and the IL-15 agonist N-803. Using a clinically relevant tumor organoid model that recapitulates the patient tumor microenvironment, the project will identify and characterize glioblastoma cell states, particularly glioma [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-40","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/P7OqMV-E","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/projects.nib.si\/trust-nk\/wp-json\/wp\/v2\/pages\/40","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/projects.nib.si\/trust-nk\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/projects.nib.si\/trust-nk\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/projects.nib.si\/trust-nk\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/projects.nib.si\/trust-nk\/wp-json\/wp\/v2\/comments?post=40"}],"version-history":[{"count":43,"href":"https:\/\/projects.nib.si\/trust-nk\/wp-json\/wp\/v2\/pages\/40\/revisions"}],"predecessor-version":[{"id":479,"href":"https:\/\/projects.nib.si\/trust-nk\/wp-json\/wp\/v2\/pages\/40\/revisions\/479"}],"wp:attachment":[{"href":"https:\/\/projects.nib.si\/trust-nk\/wp-json\/wp\/v2\/media?parent=40"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}